Understanding how brain cells affect opioid addiction and behavior in HIV patients
Function of astrocytes autophagy in brain homeostasis and opioid-induced maladaptive behavior and addiction, in the context of HIV
This study is looking at how certain brain cells called astrocytes affect behavior related to opioid addiction in people living with HIV, hoping to find new ways to understand and improve brain health and addiction treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11059084 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in how they influence behavior related to opioid addiction, particularly in individuals with HIV. The study focuses on the mechanisms by which these cells manage neurotransmitters and respond to inflammation, which may contribute to maladaptive behaviors associated with drug use. By examining the process of autophagy, which helps cells recycle components and manage energy, the research aims to uncover new insights into the relationship between brain function and addiction. Patients may benefit from a better understanding of how their brain health interacts with addiction and HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing issues related to opioid addiction.
Not a fit: Patients who do not have HIV or are not struggling with opioid addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating opioid addiction in patients with HIV.
How similar studies have performed: While the specific focus on astrocyte autophagy in the context of opioid addiction and HIV is novel, related research has shown promising results in understanding the role of brain cells in addiction.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: El-Hage, Nazira — Florida International University
- Study coordinator: El-Hage, Nazira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.