Understanding how brain cell interactions change in Alzheimer's disease
Official title: Selective interactome vulnerability across the Alzheimer’s disease spectrum
Funded at Sloan-Kettering Inst Can Research · NIH-11103343 · Data updated 2026-11-12
This study is looking at how changes in the way proteins interact in brain cells might make people more vulnerable to Alzheimer's disease, with the hope of finding new ways to help improve brain health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,047,941 |
| NIH project number | 5R01AG072599-03 |
| Project ID | NIH-11103343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at various stages of Alzheimer's disease, including those with early symptoms and those diagnosed with the condition.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the changes in protein interactions within brain cells that contribute to the vulnerability seen in Alzheimer's disease. By examining how these interactions are disrupted, the study aims to uncover mechanisms that lead to cognitive decline. The researchers will utilize advanced techniques to analyze protein-protein interactions and their effects on neuronal function. Insights gained from this research could help identify new therapeutic targets for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying mechanisms of brain cell dysfunction.
How similar studies have gone: Other research has shown promise in understanding protein interactions in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Chiosis, Gabriela — Sloan-Kettering Inst Can Research
- Study coordinator: Chiosis, Gabriela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.