Understanding how brain blood vessels work and their role in diseases like Alzheimer's
Official title: The Role of Neurovascular Interactions in the Development and Regulation of the Blood-Brain Barrier
Funded at Rutgers, the State Univ of N.j. · NIH-10922831 · Data updated 2026-11-12
This study is looking at how the blood-brain barrier works and how it can be improved to help deliver medications better for people with Alzheimer's and Parkinson's diseases, using advanced imaging techniques to see what's happening in the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $223,579 |
| NIH project number | 5R00HD103911-04 |
| Project ID | NIH-10922831 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other neurodegenerative conditions that affect the blood-brain barrier.
✕Less likely to help
Patients with conditions unrelated to neurodegenerative diseases or those without BBB involvement may not benefit from this research.
What this research studies
This research investigates the blood-brain barrier (BBB), which is crucial for maintaining a healthy environment in the brain. It focuses on the interactions between neurovascular cells and blood vessels to understand how the BBB develops and functions. By studying these interactions, the research aims to identify new ways to improve drug delivery to the brain, especially for conditions like Alzheimer's and Parkinson's diseases. The project will utilize innovative techniques, including 4-D imaging, to observe these processes in detail.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for delivering drugs to the brain, improving treatment options for neurodegenerative diseases.
How similar studies have gone: Previous research has shown promise in understanding BBB function and its implications for drug delivery, indicating that this approach has potential for success.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: O'brown, Natasha — Rutgers, the State Univ of N.j.
- Study coordinator: O'brown, Natasha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.