Understanding how brain blood vessels respond to energy changes
Cerebral Microvascular Bioenergetics and Neurovascular Coupling
This study is looking at how tiny blood vessels in the brain work with energy-producing parts of cells to keep our brain healthy, especially for people with diabetes who often experience low blood sugar, and it hopes to find out how these changes might affect thinking and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10892781 on NIH RePORTER |
What this research studies
This research investigates the role of brain microvessels in neurovascular coupling, focusing on how energy sensors in cells, specifically mitochondria, affect blood flow and brain function. The study explores the impact of recurrent hypoglycemia, a common issue for diabetes patients, on the mitochondrial function of these microvessels. By utilizing advanced technology to analyze cellular bioenergetics, the research aims to uncover the mechanisms behind cognitive impairments associated with diabetes and blood sugar fluctuations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who experience episodes of hypoglycemia.
Not a fit: Patients without diabetes or those who do not experience hypoglycemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive decline in diabetes patients.
How similar studies have performed: Other research has shown promising results in understanding the relationship between blood flow and brain function, making this approach both relevant and potentially impactful.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Katakam, Prasad V — Tulane University of Louisiana
- Study coordinator: Katakam, Prasad V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.