Understanding how brain blood flow is controlled in Alzheimer's disease
A pericyte Cl- clamp controls capillary electrical signaling and brain blood flow
This study is looking at special cells in the brain that help control blood flow, which is really important for keeping our brains healthy, and it could help us find new ways to treat Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10940608 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate blood flow in the brain, particularly focusing on a type of cell called thin-strand pericytes. These cells are located on brain capillaries and may play a crucial role in controlling blood flow, which is vital for brain health. The study aims to uncover how these pericytes influence electrical signaling in the vascular network, which could lead to new therapeutic targets for Alzheimer's disease and related dementias. By using advanced imaging techniques, the researchers will explore the interactions between these cells and blood vessels to better understand their role in maintaining proper brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow in the brains of patients with Alzheimer's disease, potentially slowing disease progression.
How similar studies have performed: While the specific mechanisms being investigated are novel, previous research has shown that understanding blood flow regulation in the brain is critical for addressing neurodegenerative diseases.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Longden, Thomas a — University of Maryland Baltimore
- Study coordinator: Longden, Thomas a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.