Understanding how brain activity helps clear waste during sleep
Administrative Core
This study is looking at how brain activity affects the movement of fluid in the brain during sleep, which could help us understand brain health and sleep problems better, and it's being done by a team of experts from different fields.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10898599 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neural activity influences the flow of cerebrospinal fluid (CSF) and the clearance of waste from the brain during sleep. It involves a collaborative effort among experts in various fields, including neuroimaging and fluid dynamics, to analyze how these processes occur across different scales and species. The Administrative Core will coordinate the research activities, facilitate data sharing, and ensure effective communication among the research teams. Patients may benefit from insights gained about brain health and sleep-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals experiencing sleep disorders or neurological conditions that may be linked to impaired waste clearance in the brain.
Not a fit: Patients with no sleep-related issues or neurological conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to brain waste clearance and sleep disorders.
How similar studies have performed: Other research has shown promising results in understanding the relationship between sleep and brain waste clearance, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Nedergaard, Maiken — University of Rochester
- Study coordinator: Nedergaard, Maiken
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.