Understanding how brain activity affects stress responses in depression
Official title: Neural activity and circuitry-mediated hippocampal stress responses
Funded at University of New Mexico Health Scis Ctr · NIH-10925411 · Data updated 2026-11-12
This study is looking at how new brain cells in a part of the brain called the hippocampus affect stress and depression, with the hope of finding better treatments for people dealing with major depressive disorder.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00MH125016-04 |
| Project ID | NIH-10925411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals experiencing major depressive disorder or related anxiety conditions.
✕Less likely to help
Patients with depression that is resistant to all forms of treatment may not receive benefit from this research.
What this research studies
This research investigates the role of newly formed neurons in the hippocampus and their impact on stress responses related to major depressive disorder (MDD). By examining how these immature neurons influence behavior and respond to antidepressant treatments, the study aims to uncover the cellular and molecular mechanisms behind MDD. Patients may benefit from insights that could lead to more effective therapies for depression based on the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for major depressive disorder.
How similar studies have gone: Previous research has shown promising results in understanding the role of neurogenesis in depression, indicating that this approach has potential for success.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Tunc-Ozcan, Elif — University of New Mexico Health Scis Ctr
- Study coordinator: Tunc-Ozcan, Elif
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.