Understanding how brain activity affects ringing in the ears and sound sensitivity
Official title: Cortical mechanisms underlying aberrant auditory perception
Funded at University of Rochester · NIH-11110523 · Data updated 2026-11-12
This study is looking into how the brain might cause ringing in the ears (tinnitus) and sensitivity to sound (hyperacusis) by examining how certain brain cells communicate, which could help find better treatments for people dealing with these issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $145,989 |
| NIH project number | 1K08DC022683-01 |
| Project ID | NIH-11110523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing tinnitus or hyperacusis, particularly those with a history of hearing loss.
✕Less likely to help
Patients without auditory disorders or those who do not experience tinnitus or hyperacusis may not benefit from this research.
What this research studies
This research investigates the brain mechanisms that may cause tinnitus, which is the perception of ringing in the ears, and hyperacusis, a condition characterized by increased sensitivity to sound. Using animal models and advanced imaging techniques, the study aims to explore how specific neuron activity and neurotransmitter signaling in the auditory and frontal cortices contribute to these auditory disorders. By examining the balance between excitation and inhibition in the brain, the research seeks to uncover the neural basis of these conditions, which could lead to better treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from tinnitus and hyperacusis.
How similar studies have gone: While the specific approach of this research is novel, prior studies have indicated that understanding the neural mechanisms of auditory disorders can lead to significant advancements in treatment.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Hayes, Sarah — University of Rochester
- Study coordinator: Hayes, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.