Understanding how brain activity affects cerebrospinal fluid flow during sleep and wakefulness
Project 4: Linking neural, hemodynamic, and multiscale cerebrospinal fluid flow measures in humans
This study is looking at how brain activity affects the flow of fluid in the brain while you sleep, especially during deep sleep, to help us better understand how your brain works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10898615 on NIH RePORTER |
What this research studies
This research investigates the relationship between neural activity and cerebrospinal fluid (CSF) flow in the human brain, particularly during non-rapid eye movement (NREM) sleep. By using advanced imaging techniques like functional MRI and EEG, the study aims to determine how patterns of brain activity influence CSF dynamics. The research will explore this connection through various tasks and spontaneous neural activity, focusing on specific brain regions involved in regulating these processes. The findings could enhance our understanding of brain function and fluid dynamics.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals who are healthy and willing to undergo brain imaging during sleep and wakefulness.
Not a fit: Patients with severe neurological disorders or those unable to participate in imaging procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved insights into brain health and the mechanisms underlying neurological conditions.
How similar studies have performed: While the specific approach of linking neural activity to CSF flow is novel, related studies have shown promising results in understanding brain dynamics and fluid interactions.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lewis, Laura Diane — University of Rochester
- Study coordinator: Lewis, Laura Diane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.