Understanding how brain activity affects blood flow and oxygen levels
Characterization of neurovascular and neurometabolic coupling of the negative BOLD response in human
This study is looking at how certain parts of the brain react when they get less oxygen during activity, using special imaging tools, to help us better understand brain health and find new ways to diagnose and treat brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10986086 on NIH RePORTER |
What this research studies
This research investigates the negative blood-oxygen-level-dependent (BOLD) response in the brain, which occurs when certain brain regions show decreased signals during activation. Using advanced imaging techniques like functional MRI and arterial spin labeling, the study aims to uncover the dynamics of this response and its relationship with cerebral blood flow and metabolic processes. By analyzing how these responses vary with different stimuli, the research seeks to provide a clearer understanding of brain function and dysfunction. This could lead to improved diagnostic and therapeutic strategies for conditions affecting brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing abnormal brain function or those with neurological conditions affecting blood flow and oxygenation in the brain.
Not a fit: Patients with stable neurological conditions that do not affect brain function or blood flow may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function, potentially leading to better treatments for neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding brain responses using similar imaging techniques, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Kim, Jung Hwan — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kim, Jung Hwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.