Understanding how botulinum neurotoxins work at a molecular level
Official title: Resolving the intoxication mechanism of botulinum neurotoxins using single molecule structural biology
Funded at State University New York Stony Brook · NIH-10931533 · Data updated 2026-11-12
This study is looking at how certain toxins from bacteria can harm cells, with a special focus on one type that might help develop new treatments for medical conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 20, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $299,979 |
| NIH project number | 5R01GM151334-02 |
| Project ID | NIH-10931533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that may be treated with botulinum neurotoxins, such as certain neurological disorders.
✕Less likely to help
Patients who do not have conditions that could be treated with botulinum neurotoxins may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which botulinum neurotoxins, produced by Clostridium botulinum, exert their toxic effects. By utilizing advanced techniques in single molecule structural biology, the study aims to uncover how these toxins deliver their harmful enzymes into cells. The focus is on understanding the differences between various types of botulinum neurotoxins, particularly type E, which is being explored for its potential in new treatment options. This research could lead to improved therapeutic applications of these neurotoxins in medicine.
Why it matters
Potential benefit: If successful, this research could enhance the safety and efficacy of botulinum toxin treatments, leading to better patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding the mechanisms of other neurotoxins, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Bowen, Mark E — State University New York Stony Brook
- Study coordinator: Bowen, Mark E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.