Understanding how Bordetella FhaB protein interacts with human cells
Investigation of the interaction of Bordetella FhaB adhesin with microtubules
This study is looking at how a specific protein from the whooping cough bacteria helps it stick to human cells, especially in newborns, to find better ways to improve vaccines against the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11091650 on NIH RePORTER |
What this research studies
This research investigates the interaction between the Bordetella FhaB adhesin protein and microtubules in human cells, focusing on its role in the virulence of Bordetella pertussis, the bacteria that causes whooping cough. The study aims to uncover how FhaB contributes to the bacteria's ability to adhere and colonize in human hosts, particularly in vulnerable populations like newborns. By examining the mechanisms of this interaction, researchers hope to identify new strategies for improving vaccine efficacy against pertussis. The methodology includes laboratory experiments that analyze the binding properties of FhaB and its effects on human cell structures.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under one year old, especially those who may be at risk for pertussis infection.
Not a fit: Patients who are older than one year or those who have already been vaccinated against pertussis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for whooping cough, particularly benefiting infants who are at the highest risk.
How similar studies have performed: Other research has shown success in understanding bacterial interactions with human cells, suggesting that this approach may yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Goulding, Celia — University of California-Irvine
- Study coordinator: Goulding, Celia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.