Understanding how bony spurs form in the jaw joint
Pathogenic mechanisms of TMJ osteophyte formation
['FUNDING_R21'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10983587
This study is looking at how bony growths in the jaw joint can cause pain and movement problems, using special mice to help find new ways to treat these issues and improve life for people with jaw pain.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10983587 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the formation of osteophytes, or bony spurs, in the temporomandibular joint (TMJ), which can lead to chronic pain and jaw movement issues. By studying genetically modified mice that mimic human conditions, researchers aim to uncover the biological processes that contribute to these deformities. The goal is to identify potential new treatments that could alleviate symptoms and improve the quality of life for affected individuals. Patients may benefit from insights gained into the underlying causes of their TMJ disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old experiencing TMJ disorders, particularly those with osteophyte formation.
Not a fit: Patients with TMJ issues not related to osteophyte formation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from TMJ-related pain and dysfunction.
How similar studies have performed: While the specific mechanisms of osteophyte formation in the TMJ are not extensively studied, similar research in other joints has shown promise in understanding and treating osteoarthritis.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOYAMA, EIKI — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: KOYAMA, EIKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.