Understanding how bones develop and repair themselves
BLR&D Research Career Scientist Award Application
This study is looking at how nerves affect bone health and healing, especially for people with osteoporosis, by using special mice to learn more about what bones need to grow and stay strong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10946712 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms that govern the development, maintenance, and repair of bones. It focuses on how sensory nerves influence bone cell activity and metabolism, particularly in the context of conditions like osteoporosis. By using mouse models with specific genetic changes, the research aims to uncover the energy requirements for bone growth and how bone metabolism interacts with overall body energy use. This could lead to new insights into how to better support bone health and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or suffering from bone-related conditions, particularly osteoporosis.
Not a fit: Patients with acute bone injuries or those not affected by bone metabolism disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone diseases such as osteoporosis, enhancing bone health and repair.
How similar studies have performed: Previous research has shown promising results in understanding bone metabolism and its relationship with overall energy regulation, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Baltimore VA Medical Center — Baltimore, United States (Active)
Researchers
- Principal investigator: Clemens, Thomas L — Baltimore VA Medical Center
- Study coordinator: Clemens, Thomas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.