Understanding how bone structure is formed and broken down
Official title: Dynamics of Bone ECM Assembly and Resorption
Funded at University of Missouri Kansas City · NIH-10981365 · Data updated 2026-11-12
This study is looking at how bone cells work together to build and break down bone tissue, which is important for understanding and improving treatments for osteoporosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri Kansas City NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $483,070 |
| NIH project number | 1R01AR083438-01A1 |
| Project ID | NIH-10981365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for osteoporosis or those with existing bone density issues.
✕Less likely to help
Patients with stable bone density and no history of bone diseases may not benefit from this research.
What this research studies
This research investigates the processes involved in the formation and breakdown of bone tissue, particularly focusing on the extracellular matrix (ECM) that supports bone structure. By using advanced imaging techniques in live cells and animals, the study aims to observe how bone cells, specifically osteoblasts and osteoclasts, interact and influence each other's activity in real-time. The goal is to uncover the dynamic nature of bone remodeling, which is crucial for developing better treatments for conditions like osteoporosis.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for osteoporosis and other bone diseases, enhancing bone health and reducing fracture risk.
How similar studies have gone: Previous research has shown promising results in understanding bone remodeling dynamics, but this approach offers novel insights that have not been extensively tested.
Where this research is happening
-
University of Missouri Kansas City
Kansas City, United States Active
Researchers
- Principal investigator: Dallas, Sarah L — University of Missouri Kansas City
- Study coordinator: Dallas, Sarah L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.