Understanding how bone stem cells function in Osteogenesis Imperfecta
Regulation of Skeletal progenitor cells in Osteogenesis Imperfecta
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11082337
This study is looking at how certain cells that help build and repair bones are affected by the collagen problems in Osteogenesis Imperfecta (OI), with the hope of finding new ways to help improve bone healing for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11082337 on ClinicalTrials.gov |
What this research studies
This research investigates the role of skeletal stem/progenitor cells in Osteogenesis Imperfecta (OI), a genetic disorder that leads to fragile bones. The study aims to explore how the abnormal structure of collagen in OI affects these stem cells and their ability to regenerate and repair bone. By examining the characteristics and functions of these cells in a specialized environment, the research seeks to uncover potential therapeutic targets for improving bone healing in OI patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Osteogenesis Imperfecta, particularly those experiencing frequent bone fractures or healing issues.
Not a fit: Patients with other bone disorders not related to Osteogenesis Imperfecta may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone healing and regeneration in patients with Osteogenesis Imperfecta.
How similar studies have performed: Previous research has shown promising results in understanding stem cell behavior in other bone disorders, suggesting potential for success in this area as well.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, DONGSU — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PARK, DONGSU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases, bone disorder, Bone Injury