Understanding how bone sarcomas respond to different drugs over time and location
The Evolution of Sarcoma Drug Sensitivity through Time and Space
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10880342
This study is looking at how different drugs work on bone tumors in kids by creating tiny versions of their tumors in the lab, so we can find out which treatments might work best for each child and understand why some treatments don’t succeed.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10880342 on ClinicalTrials.gov |
What this research studies
This research investigates the drug sensitivity of bone sarcomas, particularly in children, by developing personalized organoids from patient tumors. By screening these organoids with various drugs, the study aims to identify how the molecular characteristics of the tumors influence their response to treatment. The research also incorporates advanced genomic sequencing to explore the genetic variations within the tumors over time and across different regions. This approach seeks to provide a deeper understanding of why some treatments fail and how to improve therapeutic strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with bone sarcomas who are undergoing treatment.
Not a fit: Patients with sarcomas other than bone sarcomas or those who are not within the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for children with bone sarcomas.
How similar studies have performed: Other research has shown promise in using organoid models for drug sensitivity testing, indicating that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SORAGNI, ALICE — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SORAGNI, ALICE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers