Understanding how bone sarcomas respond to different drugs over time and across different areas of the tumor.
The Evolution of Sarcoma Drug Sensitivity through Time and Space
This study is looking at how different drugs work on bone sarcomas in children by creating tiny versions of their tumors to test which treatments might work best for each child, helping to find more effective ways to fight their cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11010048 on NIH RePORTER |
What this research studies
This research investigates the drug sensitivity of bone sarcomas, particularly in children, by developing personalized organoids from patient tumors. These organoids are used to screen a wide range of drugs to determine which are most effective for each individual tumor. The study also incorporates advanced genomic sequencing to analyze the molecular characteristics of the tumors, helping to understand how these factors influence drug response. By examining variations within the tumor over time and space, the research aims to provide insights that could lead to more effective treatments for bone sarcoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with bone sarcomas who are undergoing treatment.
Not a fit: Patients with sarcomas other than bone sarcomas may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for children with bone sarcomas.
How similar studies have performed: Previous research has shown promise in using organoid models for drug sensitivity testing, indicating potential success for this approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Soragni, Alice — University of California Los Angeles
- Study coordinator: Soragni, Alice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.