Understanding how bone marrow stem cells grow and function
Metabolic regulation of stem cell niche development and function
This project aims to learn more about how the environment in our bone marrow helps blood stem cells develop and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11093981 on NIH RePORTER |
What this research studies
Our bone marrow contains special stem cells that create all types of blood cells. These stem cells rely on a specific environment, called a niche, to grow and function properly. We don't fully understand how these niches form, are maintained, or change when the body is under stress. This project uses advanced models to explore the metabolic processes within these niches and how they influence stem cell behavior. By uncovering these fundamental mechanisms, we hope to gain insights into various blood-related diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this knowledge may seek individuals with certain blood conditions or those undergoing bone marrow treatments.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of blood disorders and potentially new ways to support healthy blood cell production.
How similar studies have performed: While the specific approach of studying PTPMT1 in stromal cells is novel, other basic science projects have successfully used animal models to understand stem cell biology.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Qu, Cheng-Kui — Emory University
- Study coordinator: Qu, Cheng-Kui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.