Understanding how bone marrow stem cells function after transplantation
Official title: Regulatory mechanisms of hematopoietic stem cell functions post-transplant
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10818900 · Data updated 2026-11-12
This study is looking at how well blood-making stem cells work after they're transplanted into patients, with the goal of finding ways to help them do their job better and improve recovery for people getting bone marrow transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $642,754 |
| NIH project number | 1R01HL167731-01A1 |
| Project ID | NIH-10818900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are undergoing or have undergone bone marrow transplantation.
✕Less likely to help
Patients who have not received a bone marrow transplant or those with conditions unrelated to hematopoietic stem cell function may not benefit from this research.
What this research studies
This research investigates the mechanisms that affect the function of hematopoietic stem cells (HSC) after they are transplanted into patients. It focuses on how these cells, which are crucial for producing blood and immune cells, lose their ability to regenerate effectively following transplantation. The study aims to identify the changes in mitochondrial function and quality control that lead to a decline in HSC performance, which could ultimately improve outcomes for patients undergoing bone marrow transplants.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of bone marrow transplants, leading to better recovery and health outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding stem cell function and mitochondrial dynamics, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Filippi, Marie-Dominique — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Filippi, Marie-Dominique
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.