Understanding how bone marrow cells affect the progression of brain tumors in young people
Official title: Bone marrow-derived myeloid cell dysregulation in malignant progression of glioma
Funded at Research Inst Nationwide Children's Hosp · NIH-11084544 · Data updated 2026-11-12
This study is looking at how certain immune cells from the bone marrow might help low-grade brain tumors in teens and young adults turn into more serious high-grade tumors, with the goal of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | July 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $456,284 |
| NIH project number | 5R01NS127984-03 |
| Project ID | NIH-11084544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults diagnosed with low-grade gliomas who are at risk of progression to high-grade gliomas.
✕Less likely to help
Patients with high-grade gliomas at diagnosis or those with other types of brain tumors may not benefit from this research.
What this research studies
This research investigates the role of bone marrow-derived myeloid cells in the progression of low-grade gliomas (LGGs) to high-grade gliomas (HGGs) in adolescents and young adults. The study aims to understand how these cells influence the immune response, particularly the reduction of anti-tumor CD8+ T and natural killer cells, which may lead to malignant transformation. By using specialized mouse models, researchers will explore the mechanisms behind these changes and identify potential pathways that could be targeted for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against gliomas, potentially improving outcomes for patients.
How similar studies have gone: Previous research has shown that targeting immune responses in gliomas can be effective, suggesting that this approach may yield promising results.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Rajappa, Prajwal — Research Inst Nationwide Children's Hosp
- Study coordinator: Rajappa, Prajwal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.