Understanding how bone cells multiply and signal during bone remodeling
Official title: Resolving the mechanism of osteoclast multinucleation and signaling in bone remodeling
Funded at University of Virginia · NIH-11138921 · Data updated 2026-11-12
This study is looking at how certain cells that break down bone work together and grow, focusing on a protein called lupus la, to find new ways to help people with bone diseases prevent bone loss.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HD110609-02 |
| Project ID | NIH-11138921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from conditions that affect bone density and health, such as osteoporosis or other osteoclast-related bone diseases.
✕Less likely to help
Patients with bone diseases not primarily related to osteoclast function may not benefit from this research.
What this research studies
This research investigates the process by which osteoclasts, the cells responsible for bone resorption, multiply and communicate during bone remodeling. By focusing on a specific protein called lupus la, the study aims to uncover how this protein influences the formation of multinucleated osteoclasts, which are crucial for maintaining bone health. The researchers will utilize advanced techniques to explore the signaling pathways involved and how disruptions in these processes can lead to bone diseases. The ultimate goal is to identify new therapeutic targets that could help prevent bone loss in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce bone loss in patients with bone diseases.
How similar studies have gone: Previous research has shown promising results in understanding osteoclast function and signaling, indicating that this approach has potential for success.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Whitlock, Jarred Marcus — University of Virginia
- Study coordinator: Whitlock, Jarred Marcus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.