Understanding how bone cells interact in Paget's Disease
Osteoclast-Osteocyte Interaction's in Paget's Disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11009898
This study is looking at how certain bone cells interact in people with Paget's Disease, which usually affects those over 50, to help us understand why bone problems happen and find better ways to treat the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11009898 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between osteoclasts and osteocytes in patients with Paget's Disease, a condition that typically affects individuals over 50 years old. The study aims to uncover the mechanisms behind the formation of focal bone lesions and the abnormal behavior of bone cells in this disease. By using animal models and analyzing patient samples, the researchers will explore how certain proteins and genetic factors contribute to the disease's progression. This could lead to a better understanding of Paget's Disease and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 50 years old who have been diagnosed with Paget's Disease.
Not a fit: Patients under 50 years old or those without Paget's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Paget's Disease, potentially reducing bone lesions and associated complications.
How similar studies have performed: Previous research has shown promising results in understanding bone remodeling processes, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KURIHARA, NORIYOSHI — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: KURIHARA, NORIYOSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.