Understanding how bone cells develop and function in health and disease
Studies of Osteoclast Lineage in Health and Diseases
This study is looking at how certain cells that help keep our bones healthy grow and move, both when we're healthy and when we have bone diseases, to find new ways to treat those conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10997406 on NIH RePORTER |
What this research studies
This research investigates the development and behavior of osteoclast progenitor cells, which are crucial for bone health. It aims to understand how these cells mature and migrate in both healthy conditions and during diseases that affect bones. By studying the mechanisms that regulate these processes, the research seeks to identify new drug targets that could lead to better treatments for bone diseases. The approach includes using specific mouse models to track the formation and movement of these cells over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bone diseases or conditions that affect bone health, such as osteoporosis or fractures.
Not a fit: Patients with no bone health issues or those who are not experiencing any bone-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for various bone diseases.
How similar studies have performed: Other research has shown promise in understanding bone cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Lorenzo, Joseph a — University of Connecticut Sch of Med/dnt
- Study coordinator: Lorenzo, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.