Understanding how bone cells are formed and regulated
Official title: Regulation of Osteoclastogenesis and Inflammatory Osteolysis
Funded at Washington University · NIH-11085201 · Data updated 2026-11-12
This study is looking at how certain cells that break down bone work and what controls them, with the goal of finding new ways to help people who are dealing with bone loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $490,690 |
| NIH project number | 5R01AR082192-03 |
| Project ID | NIH-11085201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing conditions that lead to excessive bone resorption, such as osteoporosis or inflammatory bone diseases.
✕Less likely to help
Patients with stable bone health or those not affected by bone resorption disorders may not benefit from this research.
What this research studies
This research investigates the formation and regulation of osteoclasts, the cells responsible for bone resorption, which are crucial for maintaining bone health. It explores the mechanisms that control osteoclast differentiation and activity, focusing on the role of specific proteins and signaling pathways. By studying how these processes can become disrupted, the research aims to identify potential therapeutic targets for conditions involving excessive bone loss. Patients may benefit from insights into new treatments that could help manage or prevent bone-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for preventing bone loss and improving bone health in patients.
How similar studies have gone: Previous research has shown success in understanding osteoclast regulation, but this specific approach involving ISG15 and STING is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Abu-Amer, Yousef — Washington University
- Study coordinator: Abu-Amer, Yousef
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.