Understanding how bone cells affect metabolism in obesity
Unraveling the role of osteocytes in metabolic dysfunction associated with obesity
This study is looking at how certain bone cells called osteocytes are involved in energy use in the body and how obesity can mess with that, with the hope of finding new ways to help people manage their weight and keep their bones healthy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-10890615 on NIH RePORTER |
What this research studies
This research investigates the role of osteocytes, the most abundant cells in bone, in regulating energy metabolism affected by obesity. It aims to uncover how obesity disrupts the metabolic functions of bone, particularly focusing on TGFβ signaling pathways in osteocytes. By exploring these mechanisms, the research seeks to identify potential therapeutic targets that could restore healthy energy metabolism while preserving bone health. Patients may benefit from insights that could lead to new treatments for obesity-related metabolic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and experiencing metabolic dysfunction.
Not a fit: Patients who are not obese or do not have metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve metabolic health in individuals with obesity.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between bone health and metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Dole, Neha — Univ of Arkansas for Med Scis
- Study coordinator: Dole, Neha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.