Understanding how bone-building treatments affect specific bone cells in older women
The role of osteoblast progenitors in response to bone anabolic agents
This study is looking at how a treatment called romosozumab affects bone health in post-menopausal women by examining bone samples, so we can understand why the benefits of this and another treatment, teriparatide, might decrease over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11085959 on NIH RePORTER |
What this research studies
This research investigates how anabolic therapies for osteoporosis, specifically romosozumab, impact osteoblast progenitors, which are crucial for bone health. The study will involve collecting bone-related samples from post-menopausal women undergoing treatment to analyze the effects of these therapies. By comparing samples from women treated with romosozumab and another agent, teriparatide, the research aims to uncover why the benefits of these treatments diminish over time. This approach combines clinical data with laboratory analysis to provide insights into bone regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are post-menopausal women diagnosed with osteoporosis who are receiving or have received anabolic therapy.
Not a fit: Patients who are not post-menopausal or do not have osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved osteoporosis treatments that maintain their effectiveness over time.
How similar studies have performed: Previous research has shown promising results in understanding the effects of anabolic agents on bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kronenberg, Henry M. — Massachusetts General Hospital
- Study coordinator: Kronenberg, Henry M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.