Understanding how bone blood vessels influence bone formation via Gs-GPCR signaling
Official title: Elucidating the Role of Gs-GPCR Signaling at the Bone-Vascular Interface
Funded at Northern California Institute/res/edu · NIH-11533001 · Data updated 2026-11-12
A short study to learn how a specific signaling pathway in bone blood vessels affects bone growth and healing, which could help people with bone diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2026 |
| Project end | August 14, 2027 |
| Funding year | 2026 |
| Award (this year) | $499,022 |
| NIH project number | 1R56DE035489-01A1 |
| Project ID | NIH-11533001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would include individuals with fibrous dysplasia or related bone disorders, or those contributing tissue samples for research.
✕Less likely to help
Some patients may not directly benefit if their condition is not driven by Gs-GPCR signaling in bone vasculature.
What this research studies
This project investigates how Gs-GPCR signaling in bone-vascular cells contributes to bone formation and repair. Researchers will examine cellular interactions in the bone niche beyond osteogenic cells, using the FD disease model to explore mechanisms. The effort aims to map how signals from bone blood vessels influence osteogenesis, potentially guiding new therapies for skeletal disorders. Results could reveal targets to enhance bone health in patients with osteoporosis, fractures, or skeletal dysplasias.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to promote bone growth and repair.
How similar studies have gone: Prior work shows Gs-GPCR signaling promotes bone formation in osteogenic cells, but its role in bone vasculature is less understood and still exploratory.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Wentworth, Kelly Lee — Northern California Institute/res/edu
- Study coordinator: Wentworth, Kelly Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.