Understanding how bone and cartilage work together in osteoarthritis
Osteocyte-dependent mechanisms of bone cartilage crosstalk in osteoarthritis
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10727267
This study is looking at how the cartilage and the bone underneath it work together in people with osteoarthritis and joint pain, hoping to find new ways to diagnose and treat the condition, while also figuring out if focusing on certain bone cells can help protect your joints and make you feel better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10727267 on ClinicalTrials.gov |
What this research studies
This research investigates the interaction between cartilage and subchondral bone in the context of osteoarthritis (OA) and joint pain. It aims to uncover the cellular and molecular mechanisms that govern this interaction, which could lead to new diagnostic and therapeutic strategies. By utilizing advanced imaging techniques and genetic analysis, the study seeks to identify biomarkers that can predict OA progression and pain. The research team will also explore how targeting osteocytes may help prevent joint damage and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for osteoarthritis, particularly those experiencing joint pain or with genetic predispositions.
Not a fit: Patients with advanced osteoarthritis or those who do not have joint pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to diagnose and treat osteoarthritis, potentially reducing pain and improving joint function for patients.
How similar studies have performed: Previous research has shown promise in using imaging and genetic markers to understand osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AKBAS KAYA, AYSE SERRA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: AKBAS KAYA, AYSE SERRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease