Understanding how body clocks work together to regulate health
Official title: Fundamental Mechanisms of Higher-Order Circadian Rhythms
Funded at University of Texas Hlth Science Center · NIH-10911969 · Data updated 2026-11-12
This study is looking at how the body's natural internal clocks work together, especially in the liver, to keep us healthy, and it hopes to find out what happens when these clocks get out of sync.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $387,500 |
| NIH project number | 5R35GM150618-02 |
| Project ID | NIH-10911969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing health issues related to circadian rhythm disturbances, such as sleep disorders or metabolic syndromes.
✕Less likely to help
Patients with stable circadian rhythms and no related health issues may not benefit from this research.
What this research studies
This research investigates the mechanisms behind circadian rhythms, which are the natural cycles that regulate various bodily functions. It focuses on how individual cellular clocks in different organs, particularly the liver, coordinate to maintain overall health. By using advanced molecular techniques and genetically modified mouse models, the research aims to uncover how these clocks interact and synchronize their activities. This could lead to a better understanding of how disruptions in these rhythms can affect health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing conditions related to circadian rhythm disruptions, improving overall health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding circadian rhythms, but this specific approach to studying peripheral clocks is relatively novel.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Koronowski, Kevin B — University of Texas Hlth Science Center
- Study coordinator: Koronowski, Kevin B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.