Understanding how body clocks affect lung injury and recovery
Mechanistic evaluation of the role of circadian rhythms in acute lung injury and subsequent recovery
This study is looking at how our body's internal clock affects lung injuries and recovery, especially after infections like the flu, to find new ways to help people heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10910909 on NIH RePORTER |
What this research studies
This research investigates how circadian rhythms, or the body's internal clock, influence the severity of acute lung injury and the recovery process. By studying the effects of timing on immune responses to infections like Influenza A Virus, the researchers aim to uncover mechanisms that could improve patient outcomes. The study involves both animal models and analysis of human data to explore how disruptions in circadian rhythms may lead to worse health outcomes. The ultimate goal is to identify new therapeutic targets that could enhance recovery from lung injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have experienced acute lung injury or are at risk of severe respiratory infections.
Not a fit: Patients with chronic lung conditions unrelated to acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving recovery from acute lung injuries, particularly in patients with severe infections.
How similar studies have performed: Previous research has shown that circadian rhythms can significantly impact immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sengupta, Shaon — Children's Hosp of Philadelphia
- Study coordinator: Sengupta, Shaon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.