Understanding how BMP signaling shapes development and adult health in humans and model organisms
Official title: Dissecting input-output relationships of Developmental BMP Signaling
Funded at University of North Carolina Greensboro · NIH-11567178 · Data updated 2026-11-12
A research project to uncover how the BMP signaling pathway produces specific responses in cells during development and in adult tissues, using human-related biology and model organisms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Greensboro NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HD115781-03 |
| Project ID | NIH-11567178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant since it focuses on basic biology and model systems.
✕Less likely to help
No direct patient intervention is described in this project.
What this research studies
Researchers will use advanced imaging, genetics, and biochemistry to see how chromatin context and gene regulation influence BMP signaling outcomes. They will study how a transcription factor called Zen changes chromatin to enable quick responses to BMP signals. The work will compare BMP responses across species to understand conserved mechanisms. This could illuminate how developmental decisions are made and how disruptions may affect health later in life.
Why it matters
Potential benefit: If successful, the work could improve our understanding of developmental biology and disease processes related to BMP signaling, potentially guiding future therapies.
How similar studies have gone: Previous work has shown that BMP signaling is central to development, with some conserved mechanisms across species; this project aims to expand on those findings with cutting-edge techniques.
Where this research is happening
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University of North Carolina Greensboro
Greensboro, United States Active
Researchers
- Principal investigator: Brantley, Susanna Elizabeth — University of North Carolina Greensboro
- Study coordinator: Brantley, Susanna Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.