Understanding how BMP signaling affects craniofacial development
Official title: Characterizing the cranial neural crest response to BMP signaling through gastrulation and neurulation
Funded at Johns Hopkins University · NIH-11052488 · Data updated 2026-11-12
This study is looking at how certain signals in the body help shape the cells that form our face, with the hope of finding new ways to prevent or treat birth defects like Treacher Collins syndrome and cleft palate.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $244,153 |
| NIH project number | 5R00DE029240-05 |
| Project ID | NIH-11052488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by craniofacial birth defects, such as those with 22q11 deletion syndrome or Treacher Collins syndrome.
✕Less likely to help
Patients with craniofacial conditions not related to BMP signaling may not benefit from this research.
What this research studies
This research investigates the role of BMP signaling in the development of cranial neural crest cells, which are crucial for forming facial structures such as bones and cartilage. By examining how BMP gradients influence the specification and differentiation of these cells during early development, the research aims to uncover mechanisms that could lead to new treatments for craniofacial birth defects. The study employs both live imaging and quantitative analysis to track BMP signaling throughout key developmental stages. Patients may benefit from insights gained that could inform preventative and therapeutic strategies for conditions like Treacher Collins syndrome and cleft palate.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments and preventative measures for various craniofacial birth defects.
How similar studies have gone: Previous research has shown promising results in understanding BMP signaling in craniofacial development, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Piacentino, Michael Louis — Johns Hopkins University
- Study coordinator: Piacentino, Michael Louis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.