Understanding how BMP signaling affects cell development and behavior
Official title: Dissecting input-output relationships of Developmental BMP Signaling
Funded at Duke University · NIH-10949362 · Data updated 2026-11-12
This study is looking at how cells use signals to make important decisions during development and in adult tissues, which could help us understand and treat conditions related to these processes, like developmental disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $104,838 |
| NIH project number | 1K99HD115781-01 |
| Project ID | NIH-10949362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with developmental disorders or diseases influenced by BMP signaling.
✕Less likely to help
Patients with conditions unrelated to BMP signaling or those over 21 years old may not receive benefits from this research.
What this research studies
This research investigates the BMP signaling pathway, which plays a crucial role in how cells make decisions during embryonic development and maintain adult tissues. By using advanced imaging techniques and mathematical modeling, the study aims to uncover how cells interpret different levels of BMP signals to produce specific responses. The findings could provide insights into various biological processes and diseases, potentially leading to new therapeutic approaches. Patients may benefit from a better understanding of developmental disorders and diseases linked to BMP signaling.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for developmental disorders and diseases related to BMP signaling.
How similar studies have gone: Other research has shown promising results in understanding signaling pathways in development, indicating that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Brantley, Susanna Elizabeth — Duke University
- Study coordinator: Brantley, Susanna Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.