Understanding how BMP receptors work and their role in diseases
Official title: Molecular basis for BMP receptor specialization and trafficking
Funded at University of Pennsylvania · NIH-11059045 · Data updated 2026-11-12
This study looks at how certain proteins called BMP receptors work in our bodies and how changes in these proteins can cause serious health problems like heart, lung, bone diseases, and even cancer, with the hope that understanding them better can lead to new treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 5F32HD114468-02 |
| Project ID | NIH-11059045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic mutations affecting BMP signaling, particularly those with cardiovascular, pulmonary, skeletal diseases, or certain cancers.
✕Less likely to help
Patients without mutations in BMP receptors or those not affected by related diseases may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind bone morphogenetic protein (BMP) receptors, which are crucial for various developmental processes in the body. It focuses on how mutations in these receptors can lead to serious health issues, including cardiovascular, pulmonary, and skeletal diseases, as well as cancer. By examining the specific roles of different BMP receptors and their signaling pathways, the research aims to uncover how these proteins influence cell behavior and development. Patients may benefit from insights gained into how BMP signaling can be manipulated for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to BMP receptor mutations.
How similar studies have gone: Previous research has shown promising results in understanding BMP signaling pathways, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Patel, Jeet H — University of Pennsylvania
- Study coordinator: Patel, Jeet H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.