Understanding how blood vessels in the skin change and adapt over time
Investigating the principles of physiological and pathological vascular remodeling via 4D imaging of live mouse skin
This study looks at how blood vessels in the skin grow and change over time, using special imaging to watch how the cells that line these vessels behave in live mice, with the hope of finding new ways to help treat skin problems related to blood flow.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10896267 on NIH RePORTER |
What this research studies
This research investigates the blood vessels in the skin, focusing on how they develop and adapt throughout life. Using advanced 4D imaging techniques, the study tracks the behavior of endothelial cells, which line the blood vessels, in live mice. The goal is to understand how these cells coordinate their actions in response to changes in blood flow and how this affects the overall health of the skin's vascular network. By examining both normal and injury-induced remodeling processes, the research aims to uncover mechanisms that could inform future treatments for skin-related vascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who may have conditions affecting skin vascular health.
Not a fit: Patients with acute skin injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into skin health and potential therapies for vascular-related skin conditions.
How similar studies have performed: While the specific approach of using 4D imaging in this context is novel, similar studies have shown promise in understanding vascular dynamics in other tissues.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Kam, Chen Yuan — Yale University
- Study coordinator: Kam, Chen Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.