Understanding how blood vessels in the eye respond to anti-VEGF injections for diabetic retinopathy
Characterization of vascular responses to intravitreal anti-VEGF injections in diabetic retinopathy
This work looks at how anti-VEGF eye injections affect blood flow in the eyes of people with diabetic retinopathy, using advanced imaging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11088887 on NIH RePORTER |
What this research studies
Diabetic retinopathy is a common eye condition that can lead to vision loss and blindness. While anti-VEGF injections are effective for many, we don't fully understand how they change blood flow in the eye. This project uses two advanced, non-invasive imaging techniques, adaptive optics scanning light ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA), to get a clearer picture of tiny blood vessel changes. By developing new ways to measure these changes, we hope to better track how well treatments are working and predict outcomes for patients.
Who could benefit from this research
Good fit: Patients with diabetic retinopathy who are receiving or considering anti-VEGF injections may find this research relevant to their condition.
Not a fit: Patients without diabetic retinopathy or those not undergoing anti-VEGF treatment would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to monitor treatment effectiveness for diabetic retinopathy and help doctors tailor treatments more precisely.
How similar studies have performed: While anti-VEGF therapy has shown success, previous studies on its impact on retinal blood flow have been inconsistent, making this approach to develop more sensitive metrics novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Chui, Yuen Ping Toco — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chui, Yuen Ping Toco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.