Understanding how blood vessels help clear waste in the brain related to Alzheimer's disease
Mechanisms of Vasomotion-mediated Perivascular Clearance in Cerebral Amyloid Angiopathy
This study is looking at how the blood vessels in the brain help get rid of harmful waste, like amyloid beta, which is connected to Alzheimer's disease, and it aims to find new ways to improve brain health for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10893974 on NIH RePORTER |
What this research studies
This research investigates how blood vessels in the brain facilitate the removal of harmful waste products, particularly amyloid beta, which is linked to Alzheimer's disease. The study focuses on a process called vasomotion, which involves the rhythmic contractions of blood vessel muscles that may enhance the clearance of these waste products. By examining this mechanism in detail, the researchers aim to identify potential therapeutic strategies that could improve brain health in individuals affected by cerebral amyloid angiopathy and Alzheimer's disease. The research will utilize advanced imaging techniques to observe these processes in human brain tissue.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or cerebral amyloid angiopathy.
Not a fit: Patients with other forms of dementia unrelated to amyloid beta accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance waste clearance in the brain, potentially slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of blood vessel function in brain health, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Van Veluw, Susanne Janneke — Massachusetts General Hospital
- Study coordinator: Van Veluw, Susanne Janneke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.