Understanding how blood vessels contribute to cerebral amyloid angiopathy
Role of endothelium in pathogenesis of cerebral amyloid angiopathy
This research aims to understand how blood vessel cells contribute to a brain condition called cerebral amyloid angiopathy (CAA), which often occurs with Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11129891 on NIH RePORTER |
What this research studies
Cerebral amyloid angiopathy (CAA) is a brain condition where a protein called amyloid-beta (Aβ) builds up in the walls of small blood vessels, and it often happens alongside Alzheimer's disease. Currently, there isn't a specific treatment for CAA, partly because we don't fully understand how it starts and progresses. This project explores the idea that Aβ coming from the cells lining the blood vessels in the brain plays a key role in the early stages of CAA. Researchers are studying human brain blood vessel cells and using advanced genetic tools to uncover the exact mechanisms involved.
Who could benefit from this research
Good fit: This foundational research is for future patients who may develop or are living with cerebral amyloid angiopathy or Alzheimer's disease.
Not a fit: Patients will not receive direct or immediate benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat cerebral amyloid angiopathy, potentially slowing its progression and improving outcomes for patients.
How similar studies have performed: The molecular mechanisms underlying CAA are not fully understood, making this a novel approach to identify new targets for treatment.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Katusic, Zvonimir S — Mayo Clinic Rochester
- Study coordinator: Katusic, Zvonimir S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.