Understanding How Blood Vessels Change in Health and Disease
A QUANTITATIVE, PREDICTIVE MODEL OF VASCULAR REMODELING IN HEALTH AND DISEASE
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11132940
This research aims to create a computer model that predicts how blood vessels remodel, which could help us find new treatments for heart and brain conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11132940 on ClinicalTrials.gov |
What this research studies
Our bodies' blood vessels constantly adjust to deliver nutrients and oxygen, a process called remodeling. When this process doesn't work correctly, it can lead to serious conditions like coronary artery disease, peripheral artery disease, and problems with blood flow in the brain. We are working to understand the complex signals that control blood vessel changes, especially how blood flow and growth factors interact. By collecting detailed data and using a new computer modeling method, we hope to build a predictive model of these processes.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding mechanisms relevant to individuals with coronary artery disease, peripheral artery disease, or cerebral vascular dysfunction.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not directly benefit from this early-stage modeling research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new treatment targets and the development of innovative therapies for diseases caused by faulty blood vessel remodeling.
How similar studies have performed: While many genes and proteins involved in vascular remodeling are known, this approach uses a novel computational method to integrate this knowledge into a predictive model.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWARTZ, MARTIN A — YALE UNIVERSITY
- Study coordinator: SCHWARTZ, MARTIN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Vascular Disorders, Cancers, Candidate Disease Gene