Understanding how blood vessels and neurons interact in pain
Neuron vasculature interactions in pain
['FUNDING_R01'] · UNIVERSITY OF CINCINNATI · NIH-10979939
This study is looking at how blood vessels and nerves work together to cause ongoing pain after nerve injuries, using special mice to see what happens in real-time, with the hope of finding new ways to help manage this type of pain for people who suffer from it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10979939 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between blood vessels and neurons in the context of neuropathic spontaneous pain, a challenging condition for many patients. Using genetically modified mice, researchers will observe neuronal activity in real-time to understand how nerve injuries lead to spontaneous pain. The study aims to identify the role of sympathetic activation and adrenergic receptors in this process, which could reveal new targets for pain management. By examining these interactions, the research seeks to uncover the underlying mechanisms that contribute to chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing neuropathic pain, particularly those with spontaneous pain symptoms following nerve injury.
Not a fit: Patients with acute pain not related to neuropathic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from chronic neuropathic pain.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms through similar approaches, indicating potential for success in this study.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JUN-MING — UNIVERSITY OF CINCINNATI
- Study coordinator: ZHANG, JUN-MING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.