Understanding how blood vessel structure affects glaucoma and eye pressure
Cross-species vascular anatomy and sensitivity to intraocular pressure in glaucoma
['FUNDING_R01'] · MASSACHUSETTS EYE AND EAR INFIRMARY · NIH-10694907
This study is looking at how the structure of blood vessels in the eye relates to pressure changes in people with glaucoma, which can help us understand why some areas of vision might be affected, and it's designed for anyone interested in learning more about this eye condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS EYE AND EAR INFIRMARY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10694907 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between blood vessel structure and intraocular pressure in glaucoma, a condition that can lead to vision loss. By examining the 3D architecture of the optic nerve head's vasculature in humans, monkeys, and mice, the study aims to uncover how vascular dysfunction contributes to visual field defects. The researchers will collect and analyze detailed morphological and biomechanical data to identify vulnerable regions in the eye that may be affected by elevated pressure. This comprehensive approach could lead to a better understanding of glaucoma's underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with glaucoma or those at risk of developing the condition.
Not a fit: Patients with conditions unrelated to glaucoma or those who do not have any vascular issues affecting their eyes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for managing glaucoma and preserving vision.
How similar studies have performed: Previous research has shown promising results in understanding vascular contributions to glaucoma, but this study aims to provide a more detailed and comparative analysis across species.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS EYE AND EAR INFIRMARY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIZZO, JOSEPH F. — MASSACHUSETTS EYE AND EAR INFIRMARY
- Study coordinator: RIZZO, JOSEPH F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.