Understanding how blood vessel size is regulated
Mechanistic bases of vessel diameter regulation by Plexind1 - Resubmission
This study is looking at how a certain signaling pathway affects the size of blood vessels, which is important for healthy blood flow, using zebrafish, mice, and human cells to understand how these processes work across different species.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10885991 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which a specific signaling pathway, Semaphorin-Plexind1, influences the size of blood vessels, which is crucial for proper blood flow and cardiovascular health. By using zebrafish as a model organism, the researchers will explore how blood flow and cellular signaling interact to determine vessel caliber. They will also conduct experiments with mice and human endothelial cells to confirm their findings across different species. This approach aims to uncover the fundamental processes that ensure blood vessels are correctly formed and function effectively.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cardiovascular conditions or those at risk of developing vascular abnormalities.
Not a fit: Patients with non-cardiovascular related health issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cardiovascular diseases related to abnormal blood vessel formation.
How similar studies have performed: Previous research has shown promising results in understanding vascular signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Torres-Vázquez, Jesús — New York University School of Medicine
- Study coordinator: Torres-Vázquez, Jesús
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.