Understanding how blood vessel responses differ in children with sepsis.
Official title: Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11115879 · Data updated 2026-11-12
This study is looking at how blood vessels in different organs react during sepsis, a serious infection-related condition, to find out why current treatments don't always work for kids, with the hope of discovering better ways to help them recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $401,250 |
| NIH project number | 5R35GM155165-02 |
| Project ID | NIH-11115879 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are experiencing sepsis.
✕Less likely to help
Patients who are not children or those without sepsis may not benefit from this research.
What this research studies
This research investigates the unique responses of blood vessels in different organs during sepsis, a severe condition caused by infections. By analyzing gene expression and other biological markers, the study aims to uncover why current treatments have not been effective for many patients. The approach includes high-throughput techniques to better understand the immune and endothelial responses in critically ill children. The goal is to identify targeted therapies that can improve recovery and outcomes for young patients suffering from sepsis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery rates for children with sepsis.
How similar studies have gone: While there have been numerous trials targeting inflammation in sepsis, this approach focusing on organ-specific endothelial responses is relatively novel and has not been extensively tested.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Atreya, Mihir R — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Atreya, Mihir R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.