Understanding how blood vessel problems contribute to dementia and cognitive decline
Official title: BCCMA: Interplay of Novel Mediators of Vascular Aging Pathologies
Funded at Portland VA Medical Center · NIH-11075808 · Data updated 2026-11-12
This study is looking at how problems with blood vessels might affect thinking and memory in people with vascular dementia and Alzheimer's, hoping to find new ways to help improve brain health and treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006321-02 |
| Project ID | NIH-11075808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing cognitive decline or diagnosed with vascular dementia or Alzheimer's disease.
✕Less likely to help
Patients with cognitive impairments not related to vascular issues may not benefit from this research.
What this research studies
This research investigates the relationship between vascular health and cognitive decline, particularly focusing on vascular dementia and Alzheimer's disease. It aims to uncover the mechanisms by which vascular dysfunctions in the cardiovascular and cerebrovascular systems affect cognitive functions. By studying genetic risk factors and the role of specific proteins, the research seeks to identify new pathways that could lead to better treatment strategies for dementia. Patients may benefit from insights gained into how vascular health impacts brain function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from vascular dementia and Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the links between vascular health and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Chen, Yabing — Portland VA Medical Center
- Study coordinator: Chen, Yabing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.