Understanding how blood vessel issues affect brain white matter injury and cognitive decline
Oligodendrocyte Progenitors and Mechanisms of Human Vascular White Matter Injury
This study is looking at how problems with blood vessels and certain brain cells might lead to white matter damage in people with vascular cognitive impairment and dementia, with the goal of finding new ways to help improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10618140 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind white matter injury in patients with vascular cognitive impairment and dementia. It focuses on the role of blood vessels and oligodendrocyte progenitor cells in the brain, aiming to understand how these factors contribute to the failure of myelination, which is crucial for proper brain function. The study will analyze human brain samples to explore the relationship between vascular dysfunction and the health of white matter, particularly in areas affected by oxidative stress. By linking these mechanisms, the research seeks to uncover potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline related to vascular issues.
Not a fit: Patients with cognitive impairment not related to vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with vascular cognitive impairment.
How similar studies have performed: Previous studies have shown promising results in understanding vascular contributions to cognitive decline, suggesting that this research builds on established findings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Back, Stephen Arthur — Oregon Health & Science University
- Study coordinator: Back, Stephen Arthur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.