Understanding how blood vessel health affects brain function across different ages
Lifespan Vascular Biology on White Matter
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10611788
This study is looking at how the health of your blood vessels and the brain's white matter can affect thinking skills and the risk of Alzheimer's, helping us find early signs of problems that could lead to serious issues later on, and it's especially for people from the Amish community.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10611788 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between vascular health and white matter in the brain, focusing on how these factors contribute to cognitive decline and Alzheimer's disease from adolescence through older age. By utilizing advanced imaging techniques, the study aims to identify early biomarkers and risk factors that indicate abnormal changes in white matter before they lead to irreversible damage. The research leverages data from the Amish Connectome Project, which provides a unique genetic and lifestyle context to minimize variability in results. Patients may be monitored over time to track changes in their vascular and cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 12-20 and those aged 65 and older, particularly those with risk factors for cognitive impairment.
Not a fit: Patients who are not within the specified age ranges or do not have risk factors for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early detection and intervention strategies for cognitive decline and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding vascular contributions to cognitive health, but this approach is novel in its focus on lifespan changes and early biomarkers.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MITCHELL, BRAXTON D — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MITCHELL, BRAXTON D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.