Understanding how blood vessel health affects Alzheimer's in adults with Down syndrome
Cerebrovascular contributions to Alzheimer's disease in adults with Down Syndrome
This study is looking at how blood flow in the brain affects memory and thinking in adults with Down syndrome who may have Alzheimer's disease, and it aims to help us understand how these two conditions are connected over five years.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10539086 on NIH RePORTER |
What this research studies
This research investigates the relationship between cerebrovascular health and Alzheimer's disease in adults with Down syndrome. It focuses on examining neuroimaging and blood-based markers to assess cerebrovascular dysfunction and its impact on cognitive decline. By studying a cohort of 550 adults with Down syndrome over five years, the research aims to identify how vascular health correlates with cognitive symptoms and disease progression. The study also includes postmortem analysis to further understand the role of cerebrovascular issues in Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome who are 21 years or older.
Not a fit: Patients without Down syndrome or those under 21 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease in adults with Down syndrome, potentially enhancing their quality of life.
How similar studies have performed: There is accumulating evidence suggesting that cerebrovascular health plays a significant role in Alzheimer's disease, indicating that this research builds on promising findings in related areas.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Brickman, Adam M — Columbia University Health Sciences
- Study coordinator: Brickman, Adam M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.