Understanding how blood vessel function is regulated after severe injury and during inflammation
Official title: Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation
Funded at University of South Florida · NIH-11002730 · Data updated 2026-11-12
This study is looking at how blood vessels work after injuries and during inflammation to find out why some important receptors that help control blood pressure don’t work properly in seriously ill patients, with the goal of discovering new ways to help stabilize blood pressure and improve recovery for those facing severe drops in blood pressure or shock.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $337,500 |
| NIH project number | 5R35GM152056-02 |
| Project ID | NIH-11002730 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients who experience severe hypotension or vasodilatory shock.
✕Less likely to help
Patients with stable blood pressure conditions or those not experiencing critical illness may not benefit from this research.
What this research studies
This research investigates the mechanisms that control blood vessel function, particularly after traumatic injuries and during inflammatory responses. It aims to uncover how certain receptors in the body, which are crucial for regulating blood pressure, become dysfunctional in critically ill patients. By studying these processes, the research seeks to identify new treatment strategies that could help stabilize blood pressure and improve outcomes for patients experiencing severe hypotension or shock. The approach involves both laboratory studies and analysis of biological responses to stress in animal models.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for critically ill patients suffering from severe blood pressure issues.
How similar studies have gone: Previous research has shown promise in understanding vascular function in critical illness, but this specific approach to receptor regulation is relatively novel.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Majetschak, Matthias — University of South Florida
- Study coordinator: Majetschak, Matthias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.