Understanding how blood vessel function is regulated after severe injury and during inflammation
Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation
This study is looking at how blood vessels work after injuries and during inflammation to find out why some important receptors that help control blood pressure don’t work properly in seriously ill patients, with the goal of discovering new ways to help stabilize blood pressure and improve recovery for those facing severe drops in blood pressure or shock.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11002730 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control blood vessel function, particularly after traumatic injuries and during inflammatory responses. It aims to uncover how certain receptors in the body, which are crucial for regulating blood pressure, become dysfunctional in critically ill patients. By studying these processes, the research seeks to identify new treatment strategies that could help stabilize blood pressure and improve outcomes for patients experiencing severe hypotension or shock. The approach involves both laboratory studies and analysis of biological responses to stress in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients who experience severe hypotension or vasodilatory shock.
Not a fit: Patients with stable blood pressure conditions or those not experiencing critical illness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for critically ill patients suffering from severe blood pressure issues.
How similar studies have performed: Previous research has shown promise in understanding vascular function in critical illness, but this specific approach to receptor regulation is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Majetschak, Matthias — University of South Florida
- Study coordinator: Majetschak, Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.