Understanding how blood vessel function is affected by temperature and fat tissue in Veterans
Official title: Delineating Mechanisms of Impaired Vasoreactivity in Thermoneutrality
Funded at VA Eastern Colorado Health Care System · NIH-10903738 · Data updated 2026-11-12
This study looks at how temperature and fat around blood vessels affect how well they work, especially in Veterans at risk for heart disease, to help find better ways to prevent these issues in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01BX005840-02 |
| Project ID | NIH-10903738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans who may be at risk for cardiovascular diseases due to factors like age, obesity, or other health conditions.
✕Less likely to help
Patients who do not have cardiovascular risk factors or those who are not Veterans may not benefit from this research.
What this research studies
This research investigates how temperature and the surrounding fat tissue affect blood vessel function, particularly in Veterans who are at risk for cardiovascular disease (CVD). By studying rats housed in different temperature conditions, researchers aim to understand the early signs of impaired blood vessel reactivity, which is crucial for nutrient distribution and blood pressure regulation. The study focuses on the role of perivascular adipose tissue and its transformation, which may influence blood vessel health. The findings could lead to better prevention strategies for CVD in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of cardiovascular disease in patients, particularly Veterans.
How similar studies have gone: Other research has shown promising results in understanding blood vessel function and the role of adipose tissue, suggesting that this approach could yield valuable insights.
Where this research is happening
-
VA Eastern Colorado Health Care System
Aurora, United States Active
Researchers
- Principal investigator: Keller, Amy Celeste — VA Eastern Colorado Health Care System
- Study coordinator: Keller, Amy Celeste
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.